AB-729 is currently being evaluated in a Phase 2a randomized, open-label, proof-of-concept clinical trial in combination with ongoing standard-of-care nucleos(t)ide analog therapy and short courses of Peg-IFNα-2a in 40 patients with chronic HBV infection. The primary objective of the clinical trial is to evaluate the safety and tolerability of AB-729 plus Peg-IFNα-2a in subjects with NA-suppressed chronic HBV infection. AB-729 is also being evaluated in several additional phase 2a studies with outside partners in clinical collaborations.
Data from an on-going three-part, multi-cohort Phase 1a/1b clinical trial, designed to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single- and multi-doses of AB-729, has shown that:
We believe that the magnitude and sustained reduction in HBsAg achieved with a 60 mg dose of AB-729 administered every 8 weeks has the potential to provide an important competitive advantage and is an appropriate and convenient dose to explore in future trials.